HORDB

ID: hor005724
Uniprot ID: P28674
Protein name: Neuropeptide Y
Gene name: npy
Organism: Torpedo marmorata (Marbled electric ray)
Family: NPY family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Torpedo (genus), Torpedinidae (family), Torpediniformes (order), Batoidea (superorder), Elasmobranchii (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: YPSKPDNPGEGAPAEDLAKYYSALRHYINLITRQRY
Length: 36
Propeptide: MQTNMKFWLGVFTFAFCMLICIGTFADAYPSKPDNPGEGAPAEDLAKYYSALRHYINLITRQRYGKRSSPEALMMTDLMLRENAESFPKYRYDEPFMW
Signal peptide: MQTNMKFWLGVFTFAFCMLICIGTFADA
Modification: T36 Tyrosine amide
Glycosylation: NA
Mutagenesis: NA

Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005724_AF2.pdb

hor005724_ESM.pdb

Mass:	479310	Formula:	C188H284N52O56
Absent amino acids:	CFMVW	Common amino acids:	Y
pI:	8.91	Basic residues:	6
Polar residues:	12	Hydrophobic residues:	9
Hydrophobicity:	-103.89	Boman Index:	-8675
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	65.28
Instability Index:	5469.72	Extinction Coefficient cystines:	7450
Absorbance 280nm:	212.86

PubMed ID: 1549597
Title: Strong evolutionary conservation of neuropeptide Y: sequences of chicken, goldfish, and Torpedo marmorata DNA clones.